Brain Cells That Keep Time May Have Finally Been Discovered

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Offline Mohammad Mahedi Hasan

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Brain Cells That Keep Time May Have Finally Been Discovered
« on: August 29, 2019, 12:20:15 PM »
A newly discovered type of cell in the brain keeps time so regularly that it may serve as the brain's long-hypothesized clock or metronome, report researchers.

The researchers measured the fast electrical spikes of individual neurons in the touch region of the brain to make the discovery.

This type of neuron spikes rhythmically, and in a synchronized manner, independent of external sensations, says Chris Moore, a professor of neuroscience at Brown University and the associate director of the Carney Institute for Brain Science. By "setting the beat," the neurons appear to improve rodents' ability to detect light taps on their whiskers.

Staying in Rhythm
Brain waves with approximately 40 cycles per second — also known as gamma rhythms — have been studied since the mid-1930s in humans and rodents, and earlier work from Moore's lab showed that boosting the rodents' natural gamma rhythms helped the rodents detect fainter whisker sensations.

"Gamma rhythms have been a huge topic of debate," Moore says. "Some greatly respected neuroscientists view gamma rhythms as the magic, unifying clock that align signals across brain areas. There are other equally respected neuroscientists that, colorfully, view gamma rhythms as the exhaust fumes of computation: They show up when the engine is running but they're absolutely not important."

Scientists have hypothesized the metronome-like function of the gamma rhythm before, but it has been largely written off because gamma rhythms change in response to sensations, Moore adds. These newly discovered spiking "metronome" neurons — which spike around 40 cycles a second — do not.

Moore and neuroscience doctoral student Hyeyoung Shin didn't set out to find metronome neurons, which the researchers call gamma regular nonsensory fast-spiking interneurons. Instead, initially they wanted to study the sensation-driven gamma rhythm.

Shin used a very precise machine to move whiskers slightly, just at the edge of a rodent's ability to detect movement, while recording neuron activity in the whisker-sensation part of the brain. She wanted to see what was different in the brain when the rodent was able to detect the faint tapping of its whiskers compared to when it wasn't.

"We were particularly interested in a subtype of inhibitory interneurons; these cells communicate locally and their main function is to inhibit spikes from other cells," Shin says. "We found that about one-third of these fast-spiking interneurons were 'ticking' very regularly. And ticking more regularly meant that the rodent was better able to perceive subtle sensations."

Spiking Metronome Neurons
What made her research distinctive was that she looked at the behavior of individual neurons instead of averaged neuron activity. By looking at individual neurons, she found three distinct types.

Some of these neurons spiked independent of whisker sensations and thus would typically have been ignored by scientists — this group included the subgroup of regularly spiking metronome neurons. The other two subtypes spiked randomly — some did not change with whisker sensations, and others did. Additionally, Shin found that the metronome neurons in the touch region of the brain were in synch with one another.

"There's this funny thing where neuroscientists will go into a brain, and once they find a cell that responds to the outside world, they study it," Moore says. "If it doesn't respond to the outside world, they don't know what to do with it and ignore it. With an electrode in the brain you're hearing this and you're hearing that — it's very easy to either over-interpret or miss important things entirely because you're not ready to see them."

However, Shin was ready to see these regularly spiking metronome neurons, Moore says. Prior to conducting the research, Shin conducted a deep review of the existing literature and used computer modeling to try to understand the logic of fast-spiking neurons, making this an excellent example of chance favoring the prepared mind.

Humans, Too?
Human brains also have gamma rhythms, Moore says. As a next step, he and Shin want to determine if these metronome neurons exist in primates and humans. They also want to see if metronome neurons exist in other brain regions, as well as determine if specifically enhancing the synchronicity of the metronome neurons using genetic engineering and light impacts rodents' ability to detect faint sensations.

Though metronome neurons are newly discovered, disruptions within the broader group — fast-spiking interneurons — have been implicated in a number of neurological disorders including autism, schizophrenia, and attention deficit hyperactivity disorder. It is possible that disturbances of the metronome neuron subtype cause some of these conditions, but significantly more research is needed to understand how this subtype typically functions, let alone any variations in activity.

The findings appear in the journal Neuron.

The National Institutes of Health, the Carney Institute for Brain Science, and a fellowship from the Fulbright Program supported the research.Source:Web
Mohammad Mahedi Hasan
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