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Topics - Sabreena Chowdhury Raka

Pages: 1 ... 19 20 [21]
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Pharmacy / Cytosponge - Early detection for oesophageal cancer
« on: May 10, 2017, 09:10:22 AM »
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WHO publishes list of bacteria for which new antibiotics are urgently needed

27 FEBRUARY 2017 | GENEVA - WHO today published its first ever list of antibiotic-resistant "priority pathogens" – a catalogue of 12 families of bacteria that pose the greatest threat to human health.

The list was drawn up in a bid to guide and promote research and development (R&D) of new antibiotics, as part of WHO’s efforts to address growing global resistance to antimicrobial medicines.

The list highlights, in particular, the threat of gram-negative bacteria that are resistant to multiple antibiotics. These bacteria have built-in abilities to find new ways to resist treatment and can pass along genetic material that allows other bacteria to become drug-resistant as well.

"This list is a new tool to ensure R&D responds to urgent public health needs," says Dr Marie-Paule Kieny, WHO's Assistant Director-General for Health Systems and Innovation. "Antibiotic resistance is growing, and we are fast running out of treatment options. If we leave it to market forces alone, the new antibiotics we most urgently need are not going to be developed in time."

The WHO list is divided into three categories according to the urgency of the need for new antibiotics: critical, high and medium priority.

The most critical group of all includes multidrug resistant bacteria that pose a particular threat in hospitals, nursing homes, and among patients whose care requires devices such as ventilators and blood catheters. They include Acinetobacter, Pseudomonas and various Enterobacteriaceae (including Klebsiella, E. coli, Serratia, and Proteus). They can cause severe and often deadly infections such as bloodstream infections and pneumonia.

These bacteria have become resistant to a large number of antibiotics, including carbapenems and third generation cephalosporins – the best available antibiotics for treating multi-drug resistant bacteria.

The second and third tiers in the list – the high and medium priority categories – contain other increasingly drug-resistant bacteria that cause more common diseases such as gonorrhoea and food poisoning caused by salmonella.

G20 health experts will meet this week in Berlin. Mr Hermann Gröhe, Federal Minister of Health, Germany says "We need effective antibiotics for our health systems. We have to take joint action today for a healthier tomorrow. Therefore, we will discuss and bring the attention of the G20 to the fight against antimicrobial resistance. WHO’s first global priority pathogen list is an important new tool to secure and guide research and development related to new antibiotics."

The list is intended to spur governments to put in place policies that incentivize basic science and advanced R&D by both publicly funded agencies and the private sector investing in new antibiotic discovery. It will provide guidance to new R&D initiatives such as the WHO/Drugs for Neglected Diseases initiative (DNDi) Global Antibiotic R&D Partnership that is engaging in the not-for-profit development of new antibiotics.

Tuberculosis – whose resistance to traditional treatment has been growing in recent years – was not included in the list because it is targeted by other, dedicated programmes. Other bacteria that were not included, such as streptococcus A and B and chlamydia, have low levels of resistance to existing treatments and do not currently pose a significant public health threat.

The list was developed in collaboration with the Division of Infectious Diseases at the University of Tübingen, Germany, using a multi-criteria decision analysis technique vetted by a group of international experts. The criteria for selecting pathogens on the list were: how deadly the infections they cause are; whether their treatment requires long hospital stays; how frequently they are resistant to existing antibiotics when people in communities catch them; how easily they spread between animals, from animals to humans, and from person to person; whether they can be prevented (e.g. through good hygiene and vaccination); how many treatment options remain; and whether new antibiotics to treat them are already in the R&D pipeline.

"New antibiotics targeting this priority list of pathogens will help to reduce deaths due to resistant infections around the world," says Prof Evelina Tacconelli, Head of the Division of Infectious Diseases at the University of Tübingen and a major contributor to the development of the list. "Waiting any longer will cause further public health problems and dramatically impact on patient care."

While more R&D is vital, alone, it cannot solve the problem. To address resistance, there must also be better prevention of infections and appropriate use of existing antibiotics in humans and animals, as well as rational use of any new antibiotics that are developed in future.

WHO priority pathogens list for R&D of new antibiotics

Priority 1: CRITICAL

Acinetobacter baumannii, carbapenem-resistant
Pseudomonas aeruginosa, carbapenem-resistant
Enterobacteriaceae, carbapenem-resistant, ESBL-producing

Priority 2: HIGH

Enterococcus faecium, vancomycin-resistant
Staphylococcus aureus, methicillin-resistant, vancomycin-intermediate and resistant
Helicobacter pylori, clarithromycin-resistant
Campylobacter spp., fluoroquinolone-resistant
Salmonellae, fluoroquinolone-resistant
Neisseria gonorrhoeae, cephalosporin-resistant, fluoroquinolone-resistant

Priority 3: MEDIUM

Streptococcus pneumoniae, penicillin-non-susceptible
Haemophilus influenzae, ampicillin-resistant
Shigella spp., fluoroquinolone-resistant

Source:
http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/

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Pharmacy / Oral delivery system could make vaccinations needle-free
« on: April 20, 2017, 01:33:10 PM »
Patients could one day self-administer vaccines using a needleless, pill-sized technology that jet releases a stream of vaccine inside the mouth, according to a proof-of-concept study conducted at UC Berkeley.

The study did not test vaccine delivery in people but demonstrated that the technology, called MucoJet, is capable of delivering vaccine-sized molecules to immune cells in the mouths of animals. The technology is a step toward improved oral vaccine delivery, which holds the promise of building immunity in the mouth’s buccal region of cells, where many infections enter the body. When patients hold the MucoJet against the inside of their cheek, the device releases a jet stream that directly targets the buccal region. This region is rich in immune cells but underutilised in immunology because of the challenge of efficiently penetrating the thick mucosal layer in this part of the oral cavity with existing technologies, such as the oral spray often used for influenza vaccination.

In laboratory and animal experiments, the research team showed that the MucoJet can deliver a high-pressure stream of liquid and immune system triggering molecules that penetrate the mucosal layer to stimulate an immune response in the buccal region. The jet is pressurised, but not uncomfortably so, and would remove the sting of needles.

“The jet is similar in pressure to a water pick that dentists use,” said Kiana Aran, who developed the technology while a postdoctoral scholar at Berkeley in the labs of Dorian Liepmann, a professor of mechanical and bioengineering, and Niren Murthy, a professor of bioengineering. Aran is now an assistant professor at the Keck Graduate Institute of Claremont University.

The portable technology, designed to be self-administered, stores vaccines in powder form and could one day enable vaccine delivery to remote locations, but years of further study are needed before the device would be commercially available.

Mucojet capsule held near mouth
The MucoJet technology holds promise for more effective oral vaccine delivery. (UC Berkeley photo by Stephen McNally)

The study was published March 8 in the journal Science Translational Medicine.

MucoJet is a 15-by-7-milimeter cylindrical, two-compartment plastic device. The solid components were 3D-printed from an inexpensive biocompatible and water-resistant plastic resin. The exterior compartment holds 250 millilitres of water. The interior compartment is composed of two reservoirs separated by a porous plastic membrane and a movable piston. One interior compartment is a vaccine reservoir, containing a 100-ml chamber of vaccine solution with a piston at one end and a sealed 200-micrometer (m) diameter delivery nozzle at the other end. The other interior compartment is the propellant reservoir, which contains a dry chemical propellant (citric acid and sodium bicarbonate) and is separated from the vaccine reservoir at one end by the built-in porous membrane and movable piston and is sealed at the other end from the exterior compartment with a dissolvable membrane

To administer the MucoJet, a patient clicks together with the interior and exterior compartments. The membrane dissolves, water contacts the chemical propellant and the ensuing chemical reaction generates carbon dioxide gas. The gas increases the pressure in the propellant chamber, causing the piston to move. The free-moving piston ensures uniform movement of the ejected drug and blocks the exit of fizz from the carbon dioxide through the nozzle. When the pressure in the propellant chamber is high enough, the force on the piston breaks the nozzle seal of the vaccine reservoir. The vaccine solution is then ejected from the MucoJet nozzle, penetrates the mucosal layer of the buccal tissue, and delivers the vaccine to underlying vaccine targets, called antigen-presenting cells.

Mucojet capsule in a petri dish next to a syringe
By removing the need for needle injections and allowing vaccines to be stored in the powered form, the MucoJet could allow for self-administration of vaccines, even in remote locations. (UC Berkeley photo by Stephen McNally)

To test the MucoJet’s delivery system, researchers designed a laboratory experiment in plastic dishes using mucosal layers and buccal tissues from pigs. They tested the MucoJet’s ability to deliver ovalbumim, an immune stimulating protein, across the mucosal layer. The experiments showed an eightfold increase in the delivery of ovalbumin over the course of three hours compared to a control experiment of administering ovalbumim with a dropper (similar to how oral vaccines, such as for the flu, are administered today).

The researchers then tested different pressures of the vaccine jet and found that increasing the MucoJet output pressure increased the ovalbumin delivery to the tissue, indicating that the delivery efficiency improves with increased pressure.

“The pressure is very focused, the diameter of the jet is very small, so that’s how it penetrates the mucosal layer,” Aran said.

The researchers then tested the MucoJet’s ability to deliver ovalbumim to buccal tissue in rabbits. The MucoJet delivery resulted in a sevenfold increase in the delivery of ovalbumin compared to control experiments with droppers. Animals treated with ovalbumin by MucoJet had key antibodies in their blood that were three orders of magnitude higher than in the blood from rabbits treated with ovalbumin by a dropper.

The study did not compare the MucoJet to vaccine delivery with a needle, but data suggests that the MucoJet can trigger an immune response that is as good or better than delivery with a needle, especially for mucosal pathogens.

Mucojet capsule held in fingers
The MucoJet capsule is fabricated in a 3D printer with biocompatible plastics. (UC Berkeley photo by Stephen McNally)

The next step in MucoJet’s development is to test the delivery of a real vaccine in larger animals. The researchers hope the MucoJet can be available in five to 10 years. They also hope to engineer a version of the MucoJet that can be swallowed and then release vaccines internally.

The researchers are considering other shapes, sizes and designs to simplify vaccine administration procedures and increase patient compliance, especially for children. For example, the MucoJet could be fabricated into a lollipop.

“Imagine if we could put the Mucojet in a lollipop and have kids hold it in their cheek,” Aran said. “They wouldn’t have to go to a clinic to get a vaccine.”

Sourse:
http://news.berkeley.edu/2017/03/08/oral-delivery-system-could-make-vaccination-needle-free/

307
Pharmacy / The Terrifying Cost of "Free” Websites
« on: April 18, 2017, 05:41:14 PM »

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Pharmacy / 5 Ways to Stay Positive in Negative Situations
« on: April 09, 2017, 04:37:24 PM »
We all face negative situations in our life. Someone may say something bad about you, or something you’ve worked hard on is rejected.

In situations like this it is difficult to keep a positive attitude. However we’re judged by our communications so staying positive is the professional way to react to adverse situations.

Your natural inclination is to release your inner Hulk and bash. This  negative reaction will make  the circumstances worse and you will end up filled with disappointment and anger.

You can beat negative situations by keeping a positive attitude. The attitude you take when faced with a negative situation is a choice. In the business world keeping a positive attitude in negative circumstances is a valuable skill to learn. It will keep your professional reputation intact and show you can handle any negative situation.

5 Rules to Help You Stay Positive

The best way to overcome a negative situation is by keeping a positive attitude. It is not easy and requires discipline on your part, but you can do it. At first you may not succeed every time so consider it a training program. Eventually you will learn to control your reactions out of habit.

Rule # 1 – Control Your Response

The golden rule of staying positive in a negative situation is to control your response. Take a deep breath, count to 10, do whatever it takes to remove yourself from the negativity. Wait until you calm down and have thought clearly about your response.

If you respond out of emotion you will only make it worse. Remember Thumper’s rule. “If you can’t say anything nice, then don’t say anything at all.” This is good advice when you find yourself in a negative situation.

Negative situations compound when they cause you stress. Learn how to deal with stress to remove the extra negativity.

Rule # 2 – Learn From Negative Situations

Look at a negative situation or event as an opportunity to learn and grow personally. Albert Einstein said “In the middle of difficulty lies opportunity.” Don’t channel your energy into a negative reaction, but into something positive that will make the situation better, not worse.

If you do react negatively take note of it and the circumstances that caused it. Learn from it by identifying the triggers that caused your reaction so you can watch for them in the future. Train yourself so you control the situation instead of allowing the situation to control your actions.

Rule # 3 – If You Make a Mistake, Admit it

We are human so we all make mistakes from time to time. When you do you need to step up and admit it. One thing I told my boss a long time ago was that if I ever made a mistake he would hear it from me first. If you make a mistake that leads to a negative situation, admit to it, learn from it and move on.

Rule # 4 – Maintain a Positive View

Don’t allow your opinion of someone to become jaded by a negative situation. Keep a positive view about a person or a situation and don’t jump to conclusions. Be proactive in dealing with adverse circumstances, not reactive. If the negativity is true see rule # 3. If not then affirm what you already know about yourself and your work.

When you are working under pressure it is hard to keep a positive attitude, but for a manager often pressure is part of the job. Learning how to work under pressure will help you overcome a source of negative situations.

Rule # 5 – Accentuate The Positive.

Remember that scene in The Jungle Book where Baloo breaks into a song about staying positive?

You’ve got to accentuate the positive
Eliminate the negative
And latch on to the affirmative
Don’t mess with Mister In-Between

Words of wisdom from a dancing bear.

Emphasize your positive attitude by your actions and in your words.
Eliminate any negative thoughts generated from a negative situation. Nothing good is gained from a negative reaction.
Affirm the positive truths you know to be true about yourself and your work.
Don’t flip-flop between positive and negative. When negativity comes to you remove yourself from the situation, flip to the positive side and stay there.
Take Away

In the middle of writing this piece I had to put this into practice when the power went out for 2 1/2 hours during a thunderstorm. Rather than get mad because I had lost my writing time, I grabbed a notebook and started writing my to-do list for work tomorrow. A negative reaction to something beyond my control would have wasted time and energy.

Life will continually present you with negative situations. You choose how you react to them. Rather than waste energy and your reputation by reacting negatively, learn to turn a negative situation into a positive. Don’t let the actions of others or circumstances turn you to the dark side of the workforce.

Keeping a  positive attitude in a negative situation is hard, but if you work at it you will learn to overcome your emotional reactions. Doing so will enhance your professional appearance and show that even under negative circumstances you can maintain control and deal with any issue in a positive way.

As a manager you need to teach these rules to your reports. If you have negativity coming from team members, learn how to deal with team member personalities.

Source:
http://itmanagersinbox.com/1894/5-ways-to-stay-positive-in-negative-situations/

309
Your Body is ACIDIC. Here are Very SIMPLE WAYS TO ALKALIZE YOUR BODY– AMAZING EFFECTS!

Many people who are reading this may have a high acidity level in his or her body. This is due to the typical first world diet of processed foods, refined sugars, and GMOs. However, many people do not know that an acidic body is a breeding ground for cancer, excess weight, pain and many health issues.

Fortunately, making your organism more alkaline is very simple and easy. Making alkaline environment is, in fact, the opposite of acidic environment.

Here are ten simple natural ways that you can practice every day, and they will alkalize your organism. At the same time you will gain more everyday energy and vitality:

1. The most important thing is to start your day with a smile and with a large glass of water with the juice of a freshly-squeezed lemon. Lemons have the opposite effect on your body even they may seem acidic. Drink first thing in the morning to flush the system.

Another option is to drink one or two glasses of organic apple cider vinegar and water daily. You should only mix one to two tablespoons of vinegar in eight ounces of water.

2. Eat a large portion of green salad tossed in lemon juice and quality olive oil. Greens (vegetable or fruit) are among the best sources of alkaline minerals, like calcium. Eat alkaline foods during the day like most fruits and vegetables. They sustain the body’s pH on a daily basis and keep balance in your organism.

3. Your snack should consist on raw, unsalted almonds. Almonds are full of minerals that are natural alkaline like magnesium and calcium, which help to balance out the acidity and in the same time to balance blood sugar.

4. Drink almond milk and make yourself nice berry smoothie with added green powder like spirulina, or other greens. If you have a choice between almond milk and cow’s milk, almond milk is the better option.

5. Go for a nice walk or some other exercise. It’s very important to be active. Exercise helps move acidic products so your body can better eliminate them.

6. Breathe deeply. Ideally, choose a spot that has fresh, oxygen-rich air and goes there whenever you can. While you are there, drink lots of water (and on a daily basis as well) to flush the system of waste.

7. Do not eat meat every day. If you can skip few days without meat, it will be great because eating meat every day leaves an acid residue behind. We have a lot of vegan or vegetarian recipes for you. Alkalize your body!

8. Skip dessert loaded with sugar and skip drinking soda. Sugar is one of the worst acidic foods we consume and our enemy. If you drink just ONE can of soda, you will need more than thirty glasses of neutral water to neutralise the acidity in your body!

9. Add more vegetables to your diet. Be careful; potatoes don’t count. However, sweet potatoes are a good choice but don’t make them with butter, use olive oil and Himalayan salt for baking. Peppers, Asparagus, squash, Aubergines, and other vegetables are also great choices.

10. And last but not least: Add more sprouts to your daily diet. They are extremely alkalizing and rich in nutrients and energy-boosting enzymes.

Source:
http://www.beautifulquotes.co/2017/03/your-body-is-acidic-here-are-very.html?m=1

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