Kidney The ultimate filter

[tariq]

What kidnies do in our body? A very simple answer is that they filter our blood. But if one ask how they do that? Then the answer is far too complicated that even modern science is yet arguing to to find a solution. The normal process of sieveing is basically size dependent that is larger size particle will stay in the retentate and the smaller paritcle will be in the filtrate. But for kidney there are two more imortant factors. Particle charge and particle configuration. It was found that the glomerular(Filtering unit of kidney) barrier is negatively charged and hence it resist the particle of negative charge to pass through it. Particle shape also effects the the sieveing. 

[tariq]

The glomerular barrier is consist of four different layer.
1. Podocytes
2. Glomerular Basement membrane(GBM)
3. Fenestrated endothelial cell
4. Endothelial surface layer.
All the layer has its own effect on size selectivity. It was assumed that the GBM has the main effect on charge selectivity but recent invivo study showed that the endothelium layer has the main effect on charge selectivity.   

[Tanvir Ahmed Chowdhury]

Good information

[Md. Fouad Hossain Sarker]

Very informative post.

[safiqul]

Thanks Sir for you valuable post.

[M Z Karim]

Informative post sir. Thanks.

[tasnuva]

Thanks for your informative post.

[arefin]

Thanks for the information