Biologists Create Cells With 6 DNA Letters, Instead of Just 4

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One of the first things you learn in Biology 101 is that the genetic code consists of four letters: A, T, C, and G. Each represents a chemical building block of DNA, the molecule that encodes the information necessary to build life as we know it. But what if we didn't have to settle for just four letters? Now, scientists have accomplished something once thought impossible: They've created cells with an expanded genetic alphabet that includes two more letters.

https://www.wired.com/2014/05/synthetic-dna-cells/