Glyxambi is the first prescription medication in U.S. to combine the dual mechanisms of action of SGLT2 and DPP-4 inhibitors.
The U.S. Food and Drug Administration (FDA) has approved Glyxambi (empagliflozin/linagliptin), a once-daily sodium glucose co-transporter-2 (SGLT2) inhibitor and dipeptidyl peptidase-4 (DPP-4) inhibitor fixed-dose combination for the treatment of adults with type 2 diabetes.
Medication Guide
Read this Medication Guide carefully before you start treatment and each time you get a refill. There may be new information. This information does not take the place of talking to your doctor about your medical condition or your treatment. If you have any questions, ask your doctor or pharmacist.
Important information
Serious side effects can happen to people taking Glyxambi, including:
Inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Certain medical problems make you more likely to get pancreatitis. Before you start treatment, tell your doctor if you have ever had:
inflammation of your pancreas (pancreatitis)
stones in your gallbladder (gallstones)
a history of alcoholism
high blood triglyceride levels
Stop treatment and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.
Dehydration. Glyxambi can cause some people to have dehydration (the loss of body water and salt). Dehydration may cause you to feel dizzy, faint, light-headed, or weak, especially when you stand up (orthostatic hypotension).
You may be at higher risk of dehydration if you:
have low blood pressure
take medicines to lower your blood pressure, including diuretics (water pill)
are on low sodium (salt) diet
have kidney problems
are 65 years of age or older
Vaginal yeast infection. Women who take Glyxambi may get vaginal yeast infections. Symptoms of a vaginal yeast infection include:
vaginal odor
white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese)
vaginal itching
Yeast infection of the penis (balanitis or balanoposthitis). Men who take Glyxambi may get a yeast infection of the skin around the penis. Men who are not circumcised may have swelling of the penis that makes it difficult to pull back the skin around the tip of the penis. Other symptoms of yeast infection of the penis include:
redness, itching, or swelling of the penis
rash of the penis
foul smelling discharge from the penis
pain in the skin around penis
Talk to your doctor about what to do if you get symptoms of a yeast infection of the vagina or penis. Your doctor may tell you to use an over-the-counter antifungal medicine. Talk to your doctor right away if you use an over-the-counter antifungal medicine and your symptoms do not go away.
