Patients with prediabetes who achieve normal glucose regulation â€” even transiently â€” are less likely to develop diabetes, according to a follow-up to the Diabetes Prevention Program published in the Lancet.
This observational study included some 1990 patients without diabetes who had been randomized to lifestyle intervention, metformin, or placebo during the 3.2 years of the Diabetes Prevention Program. After a 13-month bridge period, patients were then followed for an additional 5.7 years.
Patients who achieved at least one reading of normoglycemia during the treatment phase had a 56% lower risk of progression to diabetes during follow-up. The risk was further reduced the more frequently a patient achieved normal glucose levels.
Commentators write: "On the assumption that this finding is confirmed, identification of regression to normoglycemia could be an important way to stratify people into those at higher and lower risk of progression to diabetes."